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Amphibian chytridiomycosis outbreak dynamics are linked with host skin bacterial community structure / Kieran A. Bates in Nature communications, 9 (1) (12/2018) 

Public Citation [article]  inNature communications > 9 (1) (12/2018) . - 693 Titre : Amphibian chytridiomycosis outbreak dynamics are linked with host skin bacterial community structure Type de document : Imprimé Auteurs : Kieran A. Bates ; Frances C. Clare ; Simon O’Hanlon ; Jaime Bosch ; Lola Brookes ; Kevin Hopkins ; Emilia J. McLaughlin ; Olivia Daniel ; Trenton W. J. Garner ; Matthew C. Fisher ; Xavier A. Harrison Année de publication : 2018 Article en page(s) : 693 Langues : Français (fre) Catégories : [CBNPMP-Thématique] Enjeux de conservation des lacs d'altitude Lien pérenne : DOI : 10.1038/s41467-018-02967-w Permalink : https://biblio.cbnpmp.fr/index.php?lvl=notice_display&id=147849 Bates, Kieran A., Clare, Frances C., O’Hanlon, Simon, Bosch, Jaime, Brookes, Lola, Hopkins, Kevin, McLaughlin, Emilia J., Daniel, Olivia, Garner, Trenton W. J., Fisher, Matthew C., Harrison, Xavier A. 2018 Amphibian chytridiomycosis outbreak dynamics are linked with host skin bacterial community structure. Nature communications, 9(1): 693.

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Assessing the ability of swab data to determine the true burden of infection for the amphibian pathogen Batrachochytrium dendrobatidis / Frances C. Clare in EcoHealth : conservation medicine, human health, ecosystem sustainability, 13 (2016) 

Public Citation [article]  inEcoHealth : conservation medicine, human health, ecosystem sustainability > 13 (2016) . - 360-367 Titre : Assessing the ability of swab data to determine the true burden of infection for the amphibian pathogen Batrachochytrium dendrobatidis Type de document : Imprimé Auteurs : Frances C. Clare ; Olivia Daniel ; Trenton W. J. Garner ; Matthew Fischer Année de publication : 2016 Article en page(s) : 360-367 Langues : Anglais (eng) Catégories : [CBNPMP-Thématique] Lac d'altitude Résumé : Batrachochytrium dendrobatidis (Bd) is a pathogenic fungus which causes the disease chytridiomycosis in amphibians by infecting the animals’ epidermis. The most commonly applied method for the detection of Bd is the use of a sterile swab, rubbed over the keratinized areas of an amphibian and then processed to yield DNA for detection by qPCR. This method has been used to infer a threshold of lethal infection in some species; however, how reliable and reproducible the swabbing method is at detecting the true burden of infection suffered by individuals is not known. European midwife toads, Alytes obstetricans, are susceptible to chytridiomycosis and are highly parasitised by Bd across Europe. By quantifying Bd-load throughout the entire skin and comparing this to swab results taken from the same individual, we determined whether epidermal swabs provide a quantifiable and accurate indication of the true fungal burden suffered. Further, we examined whether we could infer a threshold for lethal infection based on comparison of swab data taken from infected A. obstetricans exhibiting different clinical states. From swab data, we detected significantly higher fungal burdens from moribund metamorphs compared to visually healthy individuals; however, the ability of these swab data to provide an accurate indication of the true fungal burden was not reliable. These data suggest that fungal load dynamics play an important role in disease-induced mortality in A. obstetricans at these sites, but that using swab data to infer an exact threshold for Bd-associated mortality might be inappropriate and misleading. Lien pérenne : DOI : 10.1007/s10393-016-1114-z Permalink : https://biblio.cbnpmp.fr/index.php?lvl=notice_display&id=152363 Clare, Frances C., Daniel, Olivia, Garner, Trenton W. J., Fischer, Matthew 2016 Assessing the ability of swab data to determine the true burden of infection for the amphibian pathogen Batrachochytrium dendrobatidis. EcoHealth : conservation medicine, human health, ecosystem sustainability, 13: 360-367.

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Climate forcing of an emerging pathogenic fungus across a montane multi-host community / Frances C. Clare in Philosophical Transactions Royal Society London B, 371 (2016) 

Public Citation [article]  inPhilosophical Transactions Royal Society London B > 371 (2016) . - 20150454 Titre : Climate forcing of an emerging pathogenic fungus across a montane multi-host community Type de document : Imprimé Auteurs : Frances C. Clare ; Julia B. Halder ; Olivia Daniel ; Jon Bielby ; Mikhail A. Semenov ; Thibaut Jombart ; Adeline Loyau ; Dirk S. Schmeller ; Andrew A. Cunningham ; Marcus Rowcliffe ; Trenton W. J. Garner ; Jaime Bosch ; Matthew C. Fisher Année de publication : 2016 Article en page(s) : 20150454 Langues : Anglais (eng) Catégories : [CBNPMP-Thématique] Enjeux de conservation des lacs d'altitude Résumé : Changes in the timings of seasonality as a result of anthropogenic climate change are predicted to occur over the coming decades. While this is expected to have widespread impacts on the dynamics of infectious disease through environmental forcing, empirical data are lacking. Here, we investigated whether seasonality, specifically the timing of spring ice-thaw, affected susceptibility to infection by the emerging pathogenic fungus Batrachochytrium dendrobatidis (Bd) across a montane community of amphibians that are suffering declines and extirpations as a consequence of this infection. We found a robust temporal association between the timing of the spring thaw and Bd infection in two host species, where we show that an early onset of spring forced high prevalences of infection. A third highly susceptible species (the midwife toad, Alytes obstetricans) maintained a high prevalence of infection independent of time of spring thaw. Our data show that perennially overwintering midwife toad larvae may act as a year-round reservoir of infection with variation in time of spring thaw determining the extent to which infection spills over into sympatric species. We used future temperature projections based on global climate models to demonstrate that the timing of spring thaw in this region will advance markedly by the 2050s, indicating that climate change will further force the severity of infection. Our findings on the effect of annual variability on multi-host infection dynamics show that the community-level impact of fungal infectious disease on biodiversity will need to be re-evaluated in the face of climate change. This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’. Lien pérenne : DOI : 10.1098/rstb.2015.0454 Permalink : https://biblio.cbnpmp.fr/index.php?lvl=notice_display&id=150964 Clare, Frances C., Halder, Julia B., Daniel, Olivia, Bielby, Jon, Semenov, Mikhail A., Jombart, Thibaut, Loyau, Adeline, Schmeller, Dirk S., Cunningham, Andrew A., Rowcliffe, Marcus, Garner, Trenton W. J., Bosch, Jaime, Fisher, Matthew C. 2016 Climate forcing of an emerging pathogenic fungus across a montane multi-host community. Philosophical Transactions Royal Society London B, 371: 20150454.

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Consultable Article (2016) URL